The Defiant - DeFi Podcast

Before Ethereum. Before smart contracts. Before the hype around NFTs and ICOs — Bitcoin was already experimenting.In this episode of Beyond Digital Gold we rewind to 2012–2014, when developers were pushing Bitcoin’s limits with: • Colored Coins were early real-world assets • Mastercoin, the first ICO in crypto history • Counterparty and Rare Pepes, the first NFTs • Lightning Network, Bitcoin’s first native Layer 2Featuring JR Willett, Matt Luongo, Yoni Assia, Adam Krellenstein and Elizabeth Stark, and co-hosted with Nathan from StarkWare, this episode asks a fundamental question:👉 If Bitcoin has alre...

Kain Warwick—DeFi OG and founder of Synthetix and Infinex—is back on The Defiant Podcast with Camila Russo for a no-BS conversation at a pivotal moment: Infinex just ran its INX token sale and is heading into its TGE.We get into:Why Kain believes DeFi’s biggest bottleneck isn’t “more decentralization,” but UX + distributionThe hard lesson OG DeFi learned: users won’t “learn to love complexity”—the product has to be holistically betterThe INX sale controversy: $2,500 cap → cap removed, one-year lockup stays, and why he says the sale “didn’t need...

In this interview, Camila Russo sits down with Danny Ryan — former Ethereum Foundation researcher and a key leader behind Ethereum’s shift to proof of stake — now Co-Founder & President at Etherealize, to talk about the next big wave for crypto: institutional adoption of Ethereum.Recorded in Buenos Aires during Devconnect, Danny breaks down why the mood inside banks has flipped from “we can’t touch crypto” to “if we don’t adopt it, we’ll be left behind.” We dig into what institutions actually want beyond ETFs, why the biggest opportunity isn’t “tokenizing assets” but rewiring markets from first princip...

In this episode of The Defiant Podcast, Chris Storaker sits down with Alex Garn, Chief Product Officer at Borderless, to unpack how stablecoins are quietly transforming cross-border payments — and what it actually takes to move money at scale across jurisdictions.Alex walks through Borderless’ role as an orchestration layer for global on- and off-ramps, why the company stays out of the flow of funds, and how a single API can replace dozens of fragmented integrations across local regulators, liquidity providers, and banking partners.We explore why stablecoins are moving beyond trading and DeFi collateral into real...

For consumer crypto to thrive it needs to embrace financialization to deliver a better experience, and maker sure crypto disappears everywhere else. Projects doing this right sit in an emerging sector called fantech. In this episode of the Avalanche Ecosystem Series, we explore the rise of Fantech: a new category where sports fans, music fans, creators, and event-goers become participants in real digital economies. From loyalty programs and ticketing to creator monetization and on-chain rewards, we look at how these experiences get a 10x lift when they go onchain, and why Avalanche is emerging as one of...

In this episode of The Defiant Podcast, Uniswap founder Hayden Adams joins us right as the UNIfication (Unification) proposal has moved to a final governance vote—a sweeping plan from Uniswap Labs + the Uniswap Foundation that would activate protocol fees, introduce a programmatic UNI burn, and realign how value accrues across the Uniswap ecosystem. We go deep on what’s actually inside the proposal (and what isn’t), why this moment feels like the end of one DeFi era and the start of another, and how years of “regulation by enforcement” shaped Uniswap’s product decisions—down to Hayden’s firsthand experi...

In this episode of The Defiant podcast, Camila Russo sits down in Buenos Aires (Devconnect) with Marissa Foster (Product, Ethereum Foundation) and Yoav Weiss (security researcher, Ethereum Foundation) to unpack The Trustless Manifesto and the Ethereum Interop Layer (EIL), why “trust assumptions” are quietly creeping into Ethereum’s stack, and what it will take to preserve Ethereum’s core values while making UX actually usable.We dig into the hidden places users are forced to trust intermediaries, from cross-chain interoperability and solvers to something most people never question: RPCs. Then we get practical: the guests walk through the EIL, a new ap...

In this episode of The Defiant podcast, Camila Russo sits down in Buenos Aires (Devconnect) with Marissa Foster (Product, Ethereum Foundation) and Yoav Weiss (security researcher, Ethereum Foundation) to unpack The Trustless Manifesto and the Ethereum Interop Layer (EIL), why “trust assumptions” are quietly creeping into Ethereum’s stack, and what it will take to preserve Ethereum’s core values while making UX actually usable.We dig into the hidden places users are forced to trust intermediaries, from cross-chain interoperability and solvers to something most people never question: RPCs. Then we get practical: the guests walk through the EIL, a new ap...

In this episode of The Defiant podcast we speak with Morgan Krupetsky, VP of OnChain Finance at Ava Labs, to break down one of the most significant shifts happening in crypto today: the rapid institutionalization of blockchain and Avalanche’s strategy to lead it.Morgan walks us through Avalanche’s “real-world adoption first” ethos, explaining how its unique architecture enables enterprises, fintechs, banks, governments, and consumer apps to build purpose-designed blockchains while tapping into a shared liquidity hub.

Robert Leshner — the mind behind Compound, and now the founder of Superstate — believes the next trillion-dollar shift will come from bringing the world’s assets on-chain.In this episode, Cami sits down with one of DeFi’s earliest pioneers to unpack:Why DeFi itself shouldn’t change — but assets willHow tokenized T-bills, basis strategies, and even equities are finally getting institutional tractionWhy regulatory “tailwinds,” not new laws, unlocked the RWA boomThe two competing models of tokenized stocks — and why both will winWhat happens whe...

In a world of fast-advancing technology, we are told to trust in our own research. But as the crypto space matures, scams and exploits remain a constant presence. When your assets are gone, they are gone forever, with a near-zero chance of recovery. The old mantra of "Do Your Own Research" falls short against sophisticated threats like address poisoning, advanced malware, and convincing AI deepfakes. How, then, do we build a safer Web3 without sacrificing the decentralized ideals at its core?Alex Katz, CEO of the Web3 security solution Kerberus, joins us to explore this new frontier...

In the second episode of Ecosystems: Avalanche, we track the protocol’s trajectory, which included a peak valuation of $13 billion, followed by a period of consolidation and strategic redevelopment.The Defiant founder Camila Russo and Ava Labs' Chief Strategy Officer Luigi D’Onorio DeMeo are joined by founders from BENQI, Euler Labs, and LFJ, who are building on the Avalanche protocol. The conversation covers technical upgrades such as Octane and Etna, aimed at reducing fees, and Interchain Messaging, designed to enhance interoperability between blockchains. It also addresses the strategy to onboard institutional clients, including T. Rowe Price and...

In this conversation, May Zabaneh breaks down PayPal’s move into stablecoins with PYUSD and why it matters for financial inclusion. We explore how PYUSD could lower costs for cross-border payments, deliver faster settlement, and plug directly into PayPal’s existing ecosystem. The discussion covers why PayPal built a proprietary stablecoin, early adoption and real-world use cases, and plans for international expansion. We also examine the role merchants play in crypto acceptance, how DeFi and traditional finance are converging, and why interoperability will be essential in the next phase of digital payments.Chapters00:00 PayPal’s Vision...

In Web3, we find ourselves in an age of digital phantoms, a "click-farm" era where identity is flimsy and easily fabricated. But what if reputation could be real, portable, and valuable? Animoca Brands co-founder Yat Siu returns to explore this very question, detailing a vision for a trust layer built on zero-knowledge proofs.He reveals plans for a Hong Kong dollar stablecoin, a joint venture with Standard Chartered and HKT awaiting regulatory approval, and unpacks the Mocaverse ecosystem where staking power and airdrops build a verifiable, cross-chain identity. We also explore the future of Web3 gaming, the...

In this episode of The Defiant Podcast, Vinny sits down with Ahmad Shadid—former quant trader turned founder—who redirected the 2022 GPU crunch into a decentralized GPU network and now leads a bold push toward “sovereign superintelligence”: an AI CEO framework that can govern, fund, and scale itself transparently. We unpack vibe coding (building with AI at 20x speed), how zero-knowledge proofs and decentralized networks could reshape AI, and why security must keep pace in a world moving faster than audits. We talk leadership, the democratization of software, and the next wave of founders shipping...

Avalanche says it can finally square the circle: sub‑second finality, a large decentralized validator set, and thousands of sovereign L1s connected through native messaging for shared liquidity.In the genesis episode of our new ECOSYSTEMS podcast, Camila Russo and guest cohost Luigi D’Onorio DeMeo of Ava Labs unpack the Avalanche story—from Team Rocket’s probabilistic consensus and the stadium sampling intuition, to today’s “city of chains” (C‑Chain liquidity hub, P/X chains, and customizable L1s). We discuss:How random sampling achieves speed and safety/liveness guaranteesCustomization wi...

Crypto’s next chapter isn’t a shinier coin—it’s invisible rails. In this episode, we sit down with Aryan Sheikhalian, Research Lead at CMT Digital, to unpack the shift from “crypto as an asset” to crypto as infrastructure: 24/7 markets, instant clearing and settlement, and new structured products that couldn’t exist before. We talk about tokenized equities (wrappers vs. native tokenization and why dividends/governance matter), how identity layers and ZK proofs unlock mainstream distribution through banks and fintechs, and where regulation is pushing builders toward partnerships and licensed rails.Chapters...

In this episode of The Defiant Podcast, we sit down with Paul Veradittakit, Managing Partner at Pantera Capital, to discuss the explosive growth of Solana, the future of stablecoins, and the evolution of digital asset treasury companies. Paul shares insights on Pantera's $1.2 billion Solana fund, the role of institutional capital in this crypto cycle, and why he believes Solana is poised to outperform Bitcoin and Ethereum. Tune in for a look into the next wave of blockchain innovation, from payments to gaming and beyond.Chapters00:00 - Introduction to stablecoins as a practical store of value<...

In this episode of The Defiant Podcast, we sit down with Ben Nadareski, CEO and Co-Founder of Solstice Labs, to explore DeFi on Solana and why it’s becoming a magnet for institutional adoption. Ben shares how Solstice Labs is pioneering permissionless, institutional-grade yield strategies and launching the US token, a fully collateralized stablecoin designed to unlock new levels of trust and scalability in DeFi.We dive into Solana’s unique advantages—speed, low costs, and composability—and how it’s shaking off its “meme chain” reputation to emerge as a serious contender in the blockchain space. Ben also addre...

In this episode of The Defiant Podcast, we sit down with Eli Ben-Sasson, co-founder and CEO of StarkWare, to explore how StarkNet is revolutionizing blockchain scalability with ZK proofs. From Bitcoin staking to the creation of an "integrity web," Eli shares groundbreaking insights into the future of decentralized finance, Bitcoin's execution layer, and the role of StarkNet in shaping the blockchain ecosystem. Tune in to discover how StarkNet is leading the charge in decentralization, scalability, and innovation.Chapters00:00 – Introduction to Eli Ben-Sasson & StarkWare00:24 – StarkNet’s mission: Scaling blockchain with ZK proofs01:30 – StarkWar...