The a16z Show

E997 - Big Ideas 2026: The Enterprise Orchestration Layer

Published: December 23, 2025

Duration: 22:18

AI is becoming the orchestration layer inside the enterprise.

In this episode of Big Ideas 2026, we explore the shift from isolated AI copilots to coordinated multi-agent systems that plan, analyze, and execute work across teams and tools. This is not a new feature, but a new way workflows run inside large organizations.

You will hear from Seema Amble on context extraction and coordinated agent teams, Angela Strange on why unified data and parallel workflows accelerate core replacement, Alex Immerman on multiplayer AI and execution boundaries, and David Haber on what makes these systems commercially defensible.<...