
S1E90 - G Protein-Coupled Receptors: Gq, Gs, and Gi Pathways Explained
Published: October 12, 2026
Duration: 18:24
Phenylephrine tightens blood vessels, albuterol opens the airway, and Precedex turns down the sympathetic nervous system. All three drugs send their message through G protein-coupled receptors. Sachi, a practicing CRNA and founder of The CRNA Club, starts with what a receptor is, compares the four major receptor families, and follows the Gq, Gs, and Gi pathways step by step, from the receptor to the second messenger to the effect you see at the bedside.
FREE GPCR SIGNALING CHEAT SHEET: Download the GPCR Signaling Cheat Sheet - Gq, Gs, and Gi routes, second messengers, and the hook-drug chains...