Daphne Koller - The Future of AI in Biology and Drug Discovery

Daphne Koller wrote the book that many of us learned probabilistic graphical models from, founded Coursera, and now runs insitro, which is trying to make drug discovery a machine-learning problem.

We start with the bitter lesson. She agrees with most of it and then says where it stops working: biology doesn't have enough data, structure is how people understand anything, and making a drug is a question about an intervention that hasn't happened yet, not a pattern in data you already have.

Most of the episode is about why drug discovery is hard. Ninety percent...